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Debio 025
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11-Jun-2009 The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muslce apoptosis and ultrastructural defects in Col6a1-/- mypathic mice
08-May-2009 The Cyclophilin Inhibitor Debio 025 Combined with PEG IFNα2a Significantly Reduces Viral Load in Teatment-Naïve Hepatitis C Patients
02-Feb-2009 An evaluation of the cyclophilin inhibitor Debio 025 and its potential as a treatment for chronic hepatitis C
22-Dec-2008 Debio 025, a cyclophilin binding molecule, is highly efficient in clearing HCV replicon containing cells, alone or when combined with STAT-C inhibitors
16-Sep-2008 Comparative in vitro anti-hepatitis C virus activity of a selected series of polymerase, protease and helicase inhibitors
01-Aug-2008 Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition
21-Jul-2008 Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy
01-Apr-2008 Inhibition of Human Immunodeficiency Virus Type 1 Replication in Human Cells by Debio-025, a Novel Cyclophilin Binding Agent
19-Mar-2008 Hexokinase II Detachment from Mitochondria triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels
16-Mar-2008 Genetic and Pharmacologic Inhibition of Mitochondrial-dependent Necrosis Attenuates Muscular Dystrophy
11-Mar-2008 The Cyclophilin Inhibitor Debio-025 Shows Potent Anti-Hepatitis C Effect in Patients Coinfected with Hepatitis C and Human Immunodeficiency Virus
13-Dec-2007 The Role of Cyclophilins and Cyclophilin Inhibitors in the Replication of HCV
23-Nov-2007 The cyclophilin inhibitor Debio 025 is a potent inhibitor of Hepatitis C virus replication in vitro and has unique resistance profile
30-Aug-2007 Cyclophilin inhibitors in Hepatitis C viral Infection
01-Jun-2007 Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice
25-Apr-2007 Evaluation of a cyclophilin inhibitor in Hepatitis C virus-infected chimeric mice in vivo
14-Apr-2007 Viral Kinetics During 14-day Treatment with Debio-025 Demonstrate Efficient Blocking of Viral Replication in Different HCV Genotypes without Signs of Emerging Viral Resistance
11-Apr-2007 The Reduction of both Cyclophilin B and HCV-RNA by the Cyclophilin Inhibitor Debio-025 Confirms the Importance of Cyclophilin B for HCV replication in Man
31-Mar-2007 Low Risk of Drug Interaction between the Cyclophilin Inhibitor Debio-025 and (Peg) IFNa/ribavirin in HCV
16-Jan-2007 Mitochondrial dysfunction in the pathogenesis of Ullrich congenital muscular dystrophy and prospective therapy with cyclosporins
01-Nov-2006 The cyclophilin inhibitor DEBIO-025 has a potent dual anti-HIV and anti-HCV activity in treatment-naïve HIV/HCV co-infected subjects
27-Oct-2006 Non-immunosuppressive Cyclosporin Debio-025 with Interferon shows synergistic Anti-HCV Effect in Chimeric Mouse
25-Sep-2006 Selective inhibitors of Hepatitis C virus replication
02-Sep-2006 Postconditioning and Debio-025 Prevent LV Remodelling and Reduce Mortaility Following Acute Myocardial Infarction in Mice
31-Aug-2006 Cyclosporine increases Human Immunodeficiency virus Type 1 Vector Transduction of Primary Mouse Cells
01-Jul-2006 In Vivo and in Vitro Effects of Debio-025, a non-immunosuppressive Cyclosporin A Derivative on Duchene Muscular Dystrophy
24-Jun-2006 Hepatoprotection by Cyclosporin A in Experimental Hepatitis. Sorting Desensitization of the Mitochondrial Permeablility Transition Pore from Immunosuppression
21-May-2006 The non-immunosuppressive Cyclosporin A analogue Debio-025 is a potent inhibitor of Hepatitis C virus replication in vitro
25-Apr-2006 Debio-025 is a Promising New Drug for the Treatment of Chronic Hepatitis C
24-Feb-2006 Naturally Occurring Capsid Substitutions render HIV-1 Cyclophilin A Independent in Human Cells and Trim-Cyclophilin resistant in Owl Monkey Cells
 
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