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Debio 1143, Head & Neck cancer

Debio 1143 is a small molecule that neutralizes inhibitor of apoptosis proteins (IAPs) by mimicking the activity of the natural Second Mitochondrial-derived Activator of Caspases (SMAC).Debio 1143 aims to improve cancer patient treatment outcomes by sensitizing cancer cells to the action of chemotherapy, radiotherapy, and/or immune checkpoint inhibitors. Debio 1143 is a potent orally available IAP inhibitor currently in development in Head and Neck, Ovarian, NSCLC and Breast cancer. 

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