Home Contact Center Add this

Debio 1143, Head & Neck cancer

Debio 1143 is an oral chemo-radiosensitizer that will improve cancer patient treatment outcomes. It is a small molecule that neutralizes major inhibitors of apoptosis by mimicking the activity of the natural Second Mitochondrial-derived Activator of Caspases (SMAC). Evasion of apoptosis is a hallmark of cancer and a common mechanism of resistance to current treatements through deregulated expression of the family of inhibitor of apoptosis proteins (IAPs). Debio 1143 is a potent orally available IAP inhibitor currently in development in Head and Neck, Ovarian, NSCLC and Breast cancer. 

Publications (see all publications)