Debiopharm to showcase research results of their DDR Inhibitors at the 2024 AACR Conference in San Diego

Debiopharm announces poster presentations on data for their potentially best-in class compounds: Debio 0123, a brain-penetrant WEE1 inhibitor, and Debio 0432, a selective USP1 Inhibitor

Lausanne, Switzerland – April 4th, 2024 – Debiopharm (, a privately-owned, Swiss-based biopharmaceutical company aiming to establish tomorrow’s standard-of-care to cure cancer and infectious diseases, today announced preclinical data releases for two of their compounds inhibiting the DNA-damage response (DDR) of cancer cells, including Debio 0123 [selective WEE1 inhibitor] and Debio 0432 [Selective USP1 Inhibitor] at the 2024 Annual American Association for Cancer Research (AACR) summit in San Diego, California.

“Since 2017, Debiopharm has been growing its expertise in the DDR inhibitor field, firstly through its WEE1-inhibitor Debio 0123 and through the recently in-licensed asset, targeting USP1. These posters are proof of our commitment to stay at the forefront of DDR-inhibitor development and outsmart hard-to-treat cancers through synthetic lethality or other groundbreaking combinations.” Angela Zubel, Chief Development Officer at Debiopharm

AACR 2024 Poster Presentations

Mon, April 8th
Poster display: 9:00-12:30pm
Abstract #: CT064
Poster Section: 48
Poster Board #: 14
Debiopharm compound: Debio 0123
Impact of food and high gastric pH on the bioavailability of the WEE1 inhibitor Debio 0123 assessed in a Phase 1 dose escalation study
Presenter: Anne Bellon, Clinical Pharmacology Lead

Mon, April 8th
Poster display: 1:30-5:00pm
Abstract #: 3370
Poster Section: 29
Poster Board #: 27
Debiopharm compound: Debio 0123
Title: Anti-tumor activity of Debio 0123 in combination with sacituzumab govitecan in preclinical models of breast cancer
Presenter: Luke Piggott, Principal Scientist

Tue, April 9th
Poster display: 1:30-5:00pm
Abstract #: 6507
Poster Section: 46
Poster Board #: 24
Debiopharm compound: Debio 0123
Title: Simulation driven identification of combination for the WEE1 inhibitor Debio 0123 results in synergistic effect with cabozantinib validated in vivo 
Presenter: Luke Piggott, Principal Scientist & Turbine AI

Wed, April 10th
Poster display: 9:00-12:30pm
Abstract #: 7145
Poster Section: 23
Poster Board #: 7
Debiopharm compound: Debio 0432
Title: Identification of Debio 0432 as a potent and selective USP1 inhibitor for cancer therapy
Presenter: Noemie Luong, Associate Principal Scientist

About DNA-Damage Repair (DDR)

When cells have damaged DNA, they need to undergo a repair process called DDR to be able to survive. Cancer cells rely a lot on DDR as they divide and grow uncontrollably. Inhibition of DDR, particularly in combination with other anticancer agents, prevents cancer cells from repairing their DNA, which ultimately activates a self-destruction program in cancer cells. DDR inhibitors such as Debiopharm’s WEE1 and USP1 inhibitors, are being tested in clinical and preclinical studies.

Debiopharm’s commitment to cancer patients

Debiopharm aims to develop innovative therapies that target high unmet medical needs in oncology and bacterial infections. Bridging the gap between disruptive discovery products and real-world patient reach, we identify high-potential compounds and technologies for in-licensing, clinically demonstrate their safety and efficacy, and then select large pharmaceutical commercialization partners to maximize patient access globally.

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