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Pipeline

Debiopharm International’s projects cover all molecule type proteins,
peptides, small molecules

Discovery Preclinical Phase I Phase II Phase III
xevinapant (Debio 1143), Head & Neck Cancer
Head & Neck Cancer
IAP antagonist
BTD
xevinapant*, NSCLC
NSCLC
IAP antagonist
xevinapant**, Selected solid tumors
Selected solid tumors
IAP antagonist
xevinapant***, Selected solid tumors
Selected solid tumors
IAP antagonist
naratuximab emtansine (Debio 1562), Diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma
Anti-CD37 ADC
ODD
Debio 1124, Small cell lung cancer
Small cell lung cancer
Minigastrin-Lu177
Debio 1124, Medullary thyroid cancer
Medullary thyroid cancer
Minigastrin-Lu177
Debio 0123, Oncology
Oncology
Wee1 kinase inhibitor
Debio 0228, Oncology
Oncology
CAIX-targeted radiotherapy
Debio 4028, Oncology
Oncology
IAP antagonist
afabicin (Debio 1450), ABSSSI
ABSSSI
FabI inhibitor
FT/QIDP
afabicin (Debio 1450), Bone & joint infections
Bone & joint infections
FabI inhibitor
ODD/FT/QIDP
Debio 1561, Infectious diseases
Infectious diseases
Sample prep. Technology
alisporivir (Debio 025), SARS-CoV-2
SARS-CoV-2
Cyclophilin inhibitor
alisporivir (Debio 025), GI disorders
GI disorders
Cyclophilin inhibitor
Debio 1453, N. gonorrhoeae
N. gonorrhoeae
Fabl inhibitor
CARB-X
Debio 1454/S, A. baumannii
A. baumannii
Fabl inhibitor
CARB-X
Debio 1454/M, GI disorders
GI disorders
microbiome remodeling
Takeda
*in combination with avelumab
**in combination with nivolumab
***in combination with pembrolizumab
ODD
Orphan Drug Designation
FT
Fast-Track
QIDP
Qualified Infectious Disease Product
BTD
Breakthrough Therapy Designation
CARB-X
CARB-X
Takeda
Takeda
Infectious disease
Oncology

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