Publications

Preclinical Pharmacokinetics and Efficacy of Debio 1450 (Previously AFN-1720), a Prodrug of the Staphylococcocal-specific Antibiotic Debio 1452 (Previously AFN-1252)

Tolerability, Safety and Pharmacokinetics in Healthy Subjects of Single Intravenous Doses of Debio 1450 (Previously AFN-1720), a Prodrug of the…

Identification of synergistic drug combinations with the oral HSP90 inhibitor Debio 0932 in non-small cell lung cancer and renal cell…

Design and preclinical profile of CH5183284/Debio 1347, a novel orally available and selective FGFR inhibitor acting on a gatekeeper mutant…

Inhibition of FGFR3-BAIAP2L1 fusion kinase oncogenic potential by CH5183284/Debio 1347, a compound that inhibits FGFR3 kinase activity constitutively activated by…

Debio 1143, an oral antagonist of the inhibitor of apoptosis proteins, synergistically enhances the effects of multiple standard of care…

FGFR genetic alterations as a potential predictor of the sensitivity to CH5183284/Debio 1347, a selective FGFR inhibitor with a novel…

Activity of IAP antagonist Debio 1143 as a monotherapy and in combination with standard of care agents in models of…

A simplified and Reliable Capillary Microsampling Procedure to Support Preclinical Regulatory Studies in Rodents