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Eloxatin®, Elplat®, Dacotin®, Dacplat®

A major advance in the history of cancer treatment

Oxaliplatin is a diaminocyclohexane (DACH) platin. It is the active substance of the branded Eloxatin®/Elplat®/Dacotin®/Dacplat®, which has dramatically changed the prognosis of colorectal cancer. In 1996, prior to the introduction of oxaliplatin, the standard of care for colorectal cancer was 5-fluorouracil (5-FU). Combination of oxaliplatin with 5-FU and leucovorin (FOLFOX) allowed to more than double the survival of patients with metastatic disease.

In 2000’s approval of oxaliplatin in adjuvant settings has significantly increased the number of patients cured. It is a worldwide standard treatment in metastatic colorectal cancer.

Eloxatin®, Elplat®, Dacotin®, Dacplat®

In short

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Combination of oxaliplatin with 5-FU and leucovorin (FOLFOX) allowed to more than double the survival of patients with metastatic disease.

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It is a worldwide gold standard treatment in metastatic colorectal cancer.

Overview of the products

Indications

Metastatic colorectal cancer
Adjuvant setting in colorectal cancer
Pancreatic cancer in USA and in Japan
Liver cancer in China

Product Characteristics

3 dosages: 50mg, 100mg and 200mg
IV infusion
Freeze-dried and solution formulations

Debiopharm Value Added

  • Identification of the first clinical indication (mCRC)
  • Optimization of the efficacy-safety profile
  • Clinical development leading to the first file submission registration in France

 

  • CMC Continuous life cycle management (ie: solution formulation)
  • 15 patent families covering process, combination, formulation and use

Commercial Map

  • Sanofi
    • Albania
    • Australia
    • Austria
    • Bahamas
    • Bangladesh
    • Barbados
    • Belgium
    • Bermuda
    • Bosnia and Herzegovina
    • Botswana
    • Brazil
    • Bulgaria
    • Cameroon
    • Canada
    • Cayman Islands
    • Chad
    • Chile
    • China
    • Colombia
    • Costa Rica
    • Croatia
    • Dominican Republic
    • Ecuador
    • Egypt
    • El Salvador
    • France
    • Germany
    • Greece
    • Guatemala
    • Honduras
    • Hong-kong
    • Indonesia
    • Iran
    • Iraq
    • Ireland
    • Israel
    • Italy
    • Jordan
    • Kenya
    • Kuwait
    • Lebanon
    • Luxembourg
    • Macedonia
    • Malaysia
    • Mauritius
    • Mexico
    • Moldova
    • Morocco
    • Namibia
    • Nicaragua
    • Nigeria
    • Oman
    • Pakistan
    • Panama
    • Peru
    • Philippin
    • Portugal
    • Romania
    • Russia
    • Saudi Arabia
    • Singapour
    • South Africa
    • South Korea
    • Spain
    • Switzerland
    • Taiwan
    • Thailand
    • Trinidad and Tobago
    • Turkey
    • Ukraine
    • United Arab Emirates
    • USA
    • Puerto Rico
    • Venezuela
    • Vietnam
    • Zimbabwe
  • Yakult
    • Japan
  • Dr. Reddy’s Laboratories
    • India
  • Pfizer
    • Argentina

Selected Publications

Related Press release