Our Expertise in Antibody-Drug Conjugates

For several years, we have been developing Antibody-Drug Conjugates (ADCs) and actively working to establish our own proprietary linker technology platform. With a number of our cross-functional scientific teams dedicating their workdays to the optimization of our technologies, our ambition is to develop first-in-class and best-in-class ADCs against hard-to-treat cancers.

What are ADCs?

Antibody-Drug Conjugates (ADCs) are a class of targeted therapies in which a monoclonal antibody is connected to a biologically active, small molecule cytotoxic drug cargo using a linker [1-2]. Upon docking a targeted tumor antigen at the surface of cancer cells, the ADC is internalized, and the cytotoxic cargo is released through the enzymatic cleavage of the linker. Release of the cytotoxic cargo in cancer cells will induce cell death. An essential component of the ADC is the linker, which should be stable when the antibody is circulating in the vascular system but should be labile when the ADC is internalized into cancer cells. Such features allow for improved safety and efficacy.

1. Hamilton GS.2015 2. Pettinato MC.2021

Our ADC portfolio leveraging proprietary technology

“ADCs have the potential to deliver potent cytotoxic therapy directly to tumor cells and in a safer way. We’re investing in the optimization and innovation of the 3 key ADC components: the antibody, the linker and the payload in order to generate differentiated ADCs.”

Our ADC portfolio consists of carefully selected targets with first-in-class and best-in-class potential, including Debio 1562M, a CD37-targeted ADC for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) and Debio 0532, an HER3-targeted ADC for the treatment of various solid tumors. Key partnerships also comprise options to in-license bispecific antibodies targeting HER2-HER3 and HER3-EGFR along with other undisclosed targets.

How we're applying our expertise

Multilink™ Technology

Our proprietary cleavable linker technology, allowing both high Drug cargo-Antibody Ratio (DAR) and high stability.

Novel Targets

We are exploring carefully selected targets with first-in class and best-in class potential.

ADC Partnerships

Through our strategic collaborations with SunRock, Ubix Therapeutics and Genome&Co we are building well differentiated ADCs.

Global ADC facts and figures


6. Tsuchikama, K. et al. 2024 7. Maecker, H. et al. 2023 8. Grand View Research. 2024

Get Involved

Do you have a compound?

We scout for new, innovative pharmaceutical drug candidates to go through our full drug development value chain, from preclinical to registration.

Are you interested in one of our programs?

We are looking for out-licensing partners for all projects with a focus on our clinically advanced candidates.

Join our ADC development team

Developing innovative therapies for patients is in our DNA. Is it in yours too?

Our Growing Expertise in Antibiotics